In-hospital outcomes of neonates with hypoxic-ischemic encephalopathy receiving extracorporeal membrane oxygenation

Objectiveto determine in-hospital outcomes of neonates with hypoxic ischemic encephalopathy (hie) requiring extracorporeal membrane oxygenation (ecmo).study designsingle-center retrospective study from 2005 to 2016 of neonates ≥35 weeks gestation with moderate/severe hie, requiring ecmo for persistent pulmonary hypertension of newborn (pphn).resultsour cohort (n = 20) received therapeutic hypothermia for moderate (n = 12), severe (n = 5), or undocumented severity (n = 3) of hie. during ecmo, 30% (n = 6) infants developed intracranial hemorrhage at a median (iqr) duration of 24 (20) hours. sixteen (80%) infants survived to discharge, among which 15 had mri performed; 47% (n = 7) had normal mri, 20% (n = 3) had intracranial hemorrhage and 13% (n = 2), 13% (n = 2) and 7% (n = 1) had nichd stage 1, 2, and 3 pattern of brain injury respectively.conclusionsin this high-risk population of neonates, use of ecmo was safe and efficacious as demonstrated by survival and outcomes.