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   Comparative effectiveness of drugs used to constrict the patent ductus arteriosus: a secondary analysis of the PDA-TOLERATE trial (NCT01958320)  
   
نویسنده Liebowitz Melissa ,Kaempf Joseph ,Erdeve Omer ,Bulbul Ali ,Håkansson Stellan ,Lindqvist Johanna ,Farooqi Aijaz ,Katheria Anup ,Sauberan Jason ,Singh Jaideep ,Nelson Kelly ,Wickremasinghe Andrea ,Dong Lawrence ,Hassinger Denise C. ,Aucott Susan W. ,Hayashi Madoka ,Heuchan Anne Marie ,Carey William A. ,Derrick Matthew ,Wolf Ilene Sue ,Kimball Amy ,Sankar Meera ,Leone Tina ,Perez Jorge ,Serize Arturo ,Clyman Ronald I.
منبع journal of perinatology - 2019 - دوره : 39 - شماره : 5 - صفحه:599 -607
چکیده    Objectiveto evaluate the effectiveness of drugs used to constrict patent ductus arteriosus (pda) in newborns < 28 weeks.methodswe performed a secondary analysis of the multi-center pda-tolerate trial (nct01958320). infants with moderate-to-large pdas were randomized 1:1 at 8.1 ± 2.1 days to either drug treatment (n = 104) or conservative management (n = 98). drug treatments were assigned by center rather than within center (acetaminophen: 5 centers, 27 infants; ibuprofen: 7 centers, 38 infants; indomethacin: 7 centers, 39 infants).resultsindomethacin produced the greatest constriction (compared with spontaneous constriction during conservative management): rr (95% ci) = 3.21 (2.05–5.01)), followed by ibuprofen = 2.03 (1.05–3.91), and acetaminophen = 1.33 (0.55–3.24). the initial rate of acetaminophen-induced constriction was 27%. infants with persistent moderate-to-large pda after acetaminophen were treated with indomethacin. the final rate of constriction after acetaminophen ± indomethacin was 60% (similar to the rate in infants receiving indomethacin-alone (62%)).conclusionindomethacin was more effective than acetaminophen in producing ductus constriction.
آدرس University of California, Department of Pediatrics, USA, Providence St. Vincent Medical Center, USA, Ankara University School of Medicine Children’s Hospital, Turkey, Sisli Hamidiye Etfal Training and Research Hospital, Turkey, Umea University Hospital, Sweden, Umea University Hospital, Sweden, Umea University Hospital, Sweden, Sharp Mary Birch Hospital, USA, Sharp Mary Birch Hospital, USA, University of Chicago, USA, University of Chicago, USA, Kaiser Permanente Santa Clara Medical Center, USA, Kaiser Permanente Santa Clara Medical Center, USA, Morristown Medical Center, USA, Johns Hopkins University, USA, Johns Hopkins University, USA, University of Glasgow, UK, Mayo Clinic, USA, Northshore University Health System, USA, Northshore University Health System, USA, University of California San Diego and Rady Children’s Hospital, USA, Good Samaritan Hospital, USA, Columbia University Medical Center, USA, South Miami Hospital/Baptist Health South Florida, USA, South Miami Hospital/Baptist Health South Florida, USA, University of California, Department of Pediatrics, USA
 
     
   
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