Premedication with neuromuscular blockade and sedation during neonatal intubation is associated with fewer adverse events

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Premedication with neuromuscular blockade and sedation during neonatal intubation is associated with fewer adverse events


نویسنده	Ozawa Yuri ,Ades Anne ,Foglia Elizabeth E. ,DeMeo Stephen ,Barry James ,Sawyer Taylor ,Singh Neetu ,Glass Kristen ,Jung Philipp ,Quek Bin Huey ,Johnston Lindsay ,Kim Jae ,Napolitano Natalie ,Shults Justine ,Nadkarni Vinay M. ,Nishisaki Akira
منبع	journal of perinatology - 2019 - دوره : 39 - شماره : 6 - صفحه:848 -856
چکیده	Objectiveto determine the impact of premedication for tracheal intubation (ti) on adverse ti associated events, severe oxygen desaturations, and first attempt successstudy designretrospective cohort study in neonatal intensive care units (nicu) participating in the national emergency airway registry for neonates from 10/2014 to 6/2017. premedication for ti was categorized as sedation with neuromuscular blockade, sedation only, or no medication.results2260 tis were reported from 11 nicus. adverse ti associated events occurred less often in sedation with neuromuscular blockade group (10%) as compared to sedation only (29%), or no medication group (23%), p < 0.001. the adjusted odds ratio (aor) for adverse ti associated events were: sedation with neuromuscular blockade aor 0.48 (95%ci 0.34–0.65, p < 0.001) compared to no medication.conclusionuse of sedation with neuromuscular blockade was associated with favorable ti outcomes. this study supports the recommendation for the standard use of sedation with neuromuscular blockade in non-emergency tis.

آدرس	The Children’s Hospital of Philadelphia, USA, The Children’s Hospital of Philadelphia, Division of Neonatology, Department of Pediatrics, USA, The Children’s Hospital of Philadelphia, Division of Neonatology, Department of Pediatrics, USA, WakeMed Health and Hospital, Department of Pediatrics, USA, University of Colorado School of Medicine and Children’s Hospital Colorado, Division of Neonatology, USA, University of Washington School of Medicine and Seattle Children’s Hospital, Division of Neonatology, Department of Pediatrics, USA, Dartmouth Hitchcock Medical Center, Division of Neonatology, Department of Pediatrics, USA, Penn State Health Children’s Hospital/Penn State College of Medicine, Division of Neonatology, Department of Pediatrics, USA, University Hospital Schleswing-Holstein, Campus Luebeck, Department of Pediatrics, Germany, KK Women’s and Children’s Hospital, Neonatology Department, Singapore, Yale University School of Medicine, Division of Neonatology, USA, University of California San Diego, Division of Neonatology, Department of Pediatrics, USA, The Children’s Hospital of Philadelphia PA, Respiratory Therapy Department, USA, University of Pennsylvania Perelman School of Medicine, Department of Biostatistics and Epidemiology, USA, The Children’s Hospital of Philadelphia, Department of Anesthesiology and Critical Care Medicine, USA, The Children’s Hospital of Philadelphia, Department of Anesthesiology and Critical Care Medicine, USA



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