Prenatal and postnatal inflammation-related risk factors for retinopathy of prematurity

Objectiveto evaluate the relationship between prenatal and postnatal inflammation-related risk factors and severe retinopathy of prematurity (rop).study designthe study included infants born <30 weeks in california from 2007 to 2011. multivariable log-binomial regression was used to assess the association between prenatal and postnatal inflammation-related exposures and severe rop, defined as stage 3–5 or surgery for rop.resultsof 14,816 infants, 10.8% developed severe rop. though prenatal inflammation-related risk factors were initially associated with severe rop, after accounting for the effect of these risk factors on gestational age at birth through mediation analysis, the association was non-significant (p = 0.6). postnatal factors associated with severe rop included prolonged oxygen exposure, sepsis, intraventricular hemorrhage, and necrotizing enterocolitis.conclusionpostnatal inflammation-related factors were associated with severe rop more strongly than prenatal factors. the association between prenatal inflammation-related factors and rop was explained by earlier gestational age in infants exposed to prenatal inflammation.