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Evaluating congenital syphilis in a reverse sequence testing environment
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نویسنده
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Chen May W. ,Akinboyo Ibukunoluwa C. ,Sue Paul K. ,Donohue Pamela K. ,Ghanem Khalil G. ,Detrick Barbara ,Witter Frank R. ,Page Kathleen R. ,Arav-Boger Ravit ,Golden W. Christopher
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منبع
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journal of perinatology - 2019 - دوره : 39 - شماره : 7 - صفحه:956 -963
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چکیده
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Objectivesto examine the effect of maternal reverse-sequence (rs) syphilis screening on management of infants at risk for congenital syphilis (cs) using a standardized approach.study design a retrospective study from 2011 to 2014 at an academic medical center using rs testing, involving chemiluminescent immunoassay (cia), rapid plasma reagin (rpr), and fluorescent treponemal antibody-absorption (fta-abs) assays for syphilis. clinical management and outcomes of infants born to mothers with discordant (cia+/rpr−/fta+) serology were compared with national or internal guidelines.resultssixty-three infants were classified as discordant (n = 21), presumed false positive (cia+/rpr−/fta−; n = 16), or true positive (cia+/rpr+; n = 26) based on maternal serology. only 24% of cases in the discordant group underwent recommended full evaluation. none of the evaluated infants in the discordant group (n = 8) were diagnosed with cs.conclusionsmanagement of infants with discordant maternal rs serology remained reliant on clinical judgment. in our high-risk population, rs testing did not identify additional cases of cs.
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آدرس
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Johns Hopkins School of Medicine, Division of Neonatology, Department of Pediatrics, USA, Johns Hopkins University School of Medicine, Division of Pediatric Infectious Diseases, Department of Pediatrics, USA. Duke University School of Medicine, Division of Pediatric Infectious Diseases, Department of Pediatrics, USA, Johns Hopkins University School of Medicine, Division of Pediatric Infectious Diseases, Department of Pediatrics, USA. University of Texas Southwestern Medical Center, Division of Pediatric Infectious Diseases, Department of Pediatrics, USA, Johns Hopkins School of Medicine, Division of Neonatology, Department of Pediatrics, USA, Johns Hopkins University School of Medicine, Division of Infectious Diseases, Department of Medicine, USA, Johns Hopkins University School of Medicine, Division of Immunopathology, Department of Pathology, USA, Johns Hopkins University School of Medicine, Division of Maternal-Fetal Medicine, Department of Gynecology and Obstetrics, USA, Johns Hopkins University School of Medicine, Division of Infectious Diseases, Department of Medicine, USA, Johns Hopkins University School of Medicine, Division of Pediatric Infectious Diseases, Department of Pediatrics, USA. Medical College of Wisconsin, Division of Pediatric Infectious Diseases, Department of Pediatrics, USA, Johns Hopkins School of Medicine, Division of Neonatology, Department of Pediatrics, USA
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Authors
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