Hypertensive disorders during pregnancy are associated with reduced severe intraventricular hemorrhage in very-low-birth-weight infants

Objectiveto determine differences in severe intraventricular hemorrhage (ivh) between very-low-birth-weight (≤1500 g, vlbw) infants born to mothers with and without hypertensive disorders (hd).design/methodsretrospective analysis from the optum neonatal database. the primary outcome of interest was severe ivh (grade 3 or 4). secondary outcomes included other neonatal morbidities, mortality, and length of hospitalization. outcomes were compared between vlbw infants born to mothers with and without hd.resultsa total of 5456 infants met inclusion criteria. after multivariable regression analysis, risks of severe ivh and bronchopulmonary dysplasia (bpd) were lower ([or 0.42, 95% ci 0.33–0.89, p = 0.01] and [or 0.75, 95% ci 0.58–0.97, p = 0.03], respectively) and median length of hospitalization was decreased in the hd group (49 versus 61 days, p < 0.001).conclusionsvlbw infants born to mothers with hd have a decreased risk of severe ivh, bpd, and a shorter duration of hospitalization.