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   Multi-component lipid emulsion vs soy-based lipid emulsion for very low birth weight preterm neonates: A pre-post comparative study  
   
نویسنده Torgalkar Ranjit ,Dave Shruti ,Shah Jyotsna ,Ostad Nastaran ,Kotsopoulos Kirsten ,Unger Sharon ,Shah Prakesh S.
منبع journal of perinatology - 2019 - دوره : 39 - شماره : 8 - صفحه:1118 -1124
چکیده    Objectiveto examine the effectiveness of soybean oil-medium chain triglycerides-olive oil-fish oil lipid emulsion (smof-le) on clinical outcomes of very-low-birth-weight neonates.study designwe conducted a pre-post comparative study of very-low-birth-weight neonates, dividing them according to lipid emulsion received: intralipid (soy-based; n = 680) or smof-le (n = 617). primary outcomes were mortality, chronic lung disease, severe retinopathy, infection, and necrotising enterocolitis. secondary outcomes were cholestasis, osteopenia, time to full feeds, and time to regain birthweight.resultsbaseline characteristics between groups were comparable. primary outcomes did not differ significantly between groups, although any retinopathy was significantly lower in the smof-le group. smof-le group had lower odds of cholestasis, osteopenia, and lipid interruption, and reduced times to full feeds and to regain birthweight.conclusionscompared with intralipid, smof-le was not associated with differences in mortality and major morbidities but was associated with lower odds of any retinopathy, cholestasis, and osteopenia; and improved lipid tolerance.
آدرس Mount Sinai Hospital, Department of Pediatrics, Canada, Mount Sinai Hospital, Department of Pediatrics, Canada, Mount Sinai Hospital, Department of Pediatrics, Canada, Mount Sinai Hospital, Department of Pediatrics, Canada, Mount Sinai Hospital, Department of Pediatrics, Canada, Mount Sinai Hospital, Department of Pediatrics, Canada, Mount Sinai Hospital, Department of Pediatrics, Canada. University of Toronto, Department of Pediatrics, Canada
 
     
   
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