Early predictors of continuous positive airway pressure failure in preterm neonates

Objectiveto develop a prediction model to identify infants admitted on continuous positive airway pressure (cpap) requiring intubation within seventy-two hours of life (hol).study designinfants born ≤29 weeks’ gestational age between 2013 and april 2018 were randomly assigned to either a modeling cohort (mc) or a validation cohort (vc) in a 2:1 ratio. variables available within two hol were compared between the cpap failure group (cfg) and the cpap success group (csg).resultsof the 189 infants in the mc, 50% failed cpap. compared to csg, infants in the cfg had lower antenatal steroid exposure, birth weight, higher radiographic severe respiratory distress syndrome (rds) and fraction of inspired oxygen (fio2). a forward stepwise logistic regression modeling in both mc and vc showed that fio2 >0.3 and radiographic severe rds predicted cpap failure.conclusionfio2 >0.3 within two hol and radiographic severe rds predicts cpap failure in preterm infants.