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Neurodevelopmental outcomes in infants treated with intravitreal bevacizumab versus laser
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نویسنده
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Raghuram Kamini ,Isaac Maram ,Yang Junmin ,AlAli Alaa ,Mireskandari Kamiar ,Ly Linh G. ,Kelly Edmond ,Banihani Rudaina ,Shah Prakesh S. ,Tehrani Nasrin
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منبع
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journal of perinatology - 2019 - دوره : 39 - شماره : 9 - صفحه:1300 -1308
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چکیده
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Objectiveto compare neurodevelopmental and visual outcomes in preterm infants treated with intravitreal bevacizumab (ivb) to laser ablation at 18–24 months corrected age.study designa retrospective study was performed. the primary outcome was neurodevelopmental impairment (ndi). secondary neurodevelopmental outcomes were significant ndi (sndi), cerebral palsy, hearing loss, and composite scores of the bayley scales of infant development, third edition. visual outcomes included structural and refractive outcomes. adjusted odds ratios (aor) were calculated controlling for ga, sex, and rop severity and confounding baseline characteristics using a cutoff of p < 0.20.resultsthirty-four (60 eyes) infants receiving ivb and 30 (51 eyes) laser were included. no significant differences were identified in ndi (aor 1.77, 95% ci 0.46, 6.73) or sndi (aor 2.31, 95% ci 0.75, 7.14). there were no other differences in outcomes.conclusionslarger randomized trials are required to establish long-term efficacy and safety of ivb in preterm neonates.
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آدرس
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University of Toronto, Division of Neonatology, Department of Pediatrics, Canada, The Hospital for Sick Children, Department of Ophthalmology and Vision Sciences, Canada, Mount Sinai Hospital, Department of Pediatrics, Canada, University of Toronto, Department of Ophthalmology and Vision Sciences, Canada, The Hospital for Sick Children, Department of Ophthalmology and Vision Sciences, Canada. University of Toronto, Department of Ophthalmology and Vision Sciences, Canada, The Hospital for Sick Children, Division of Neonatology Department of Paediatrics, Canada. University of Toronto, Department of Paediatrics, Canada, Mount Sinai Hospital, Department of Pediatrics, Canada. University of Toronto, Department of Paediatrics, Canada, University of Toronto, Department of Paediatrics, Canada. Sunnybrook Health Sciences Centre, Department of Newborn and Developmental Paediatrics, Canada, Mount Sinai Hospital, Department of Pediatrics, Canada. University of Toronto, Department of Paediatrics, Canada, The Hospital for Sick Children, Department of Ophthalmology and Vision Sciences, Canada. University of Toronto, Department of Ophthalmology and Vision Sciences, Canada
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Authors
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