Race differences in the association between multivitamin exposure and wheezing in preterm infants

Objective:we aimed to determine whether vitamin d exposure, as estimated by use of multivitamins, is positively or negatively associated with recurrent wheezing in infants born preterm.study design:this prospective cohort study enrolled 300 infants, born at 280/7 to 346/7 weeks gestational age, and conducted follow-up at 3-, 6-, 9- and 12-month adjusted age.result:black (55.9%) and non-black (36.6%) infants experienced recurrent wheezing. adjusted odds ratios (ors) for the association between multivitamin exposure at 3 months and recurrent wheezing were 2.15 (95% confidence interval (ci): 0.97, 4.75) for black and 0.43 (95% ci: 0.19, 0.96) for non-black infants with an interaction by race (p=0.003). in lag-effect models, ors were 2.69 (95% ci: 1.41, 5.14) for black and 0.50 (95% ci: 0.27, 0.92) for non-black infants.conclusion:differences by race were seen in association between multivitamins and wheezing; population heterogeneity should be considered when evaluating vitamin supplementation.