Outcomes of extremely preterm infants after delivery room cardiopulmonary resuscitation in a population-based cohort

Objective:to describe the relationship of delivery room cardiopulmonary resuscitation (dr-cpr) to short-term outcomes of extremely preterm infants.study design:this was a cohort study of 22 to 27+6/7 weeks gestational age (ga) infants during 2005 to 2011. dr-cpr was defined as chest compressions and/or epinephrine administration. multivariable logistic regression was used to estimate odds ratios (ors) with 95% confidence intervals (cis) associated with dr-cpr; analysis was stratified by ga.result:of the 13 758 infants, 856 (6.2%) received dr-cpr. infants 22 to 23+6/7 weeks receiving dr-cpr had similar outcomes to non-recipients. infants 24 to 25+6/7 weeks receiving dr-cpr had more severe intraventricular hemorrhage (or 1.36, 95% ci 1.07, 1.72). infants 26 to 27+6/7 weeks receiving dr-cpr were more likely to die (or 1.81, 95% ci 1.30, 2.51) and have intraventricular hemorrhage (or 2.10, 95% ci 1.56, 2.82). adjusted hospital dr-cpr rates varied widely (median 5.7%).conclusion:premature infants receiving dr-cpr had worse outcomes. mortality and morbidity varied by ga.