Association between an abnormal cerebroplacental ratio and the development of severe pre-eclampsia

Objective:to study the association between the cerebroplacental ratio (cpr) and the development of pre-eclampsia.study design:three study groups were determined: group 1—normal umbilical artery (ua; referent), group 2—abnormal ua and normal cpr and group 3—abnormal ua and an abnormal cpr. the primary outcome was the development of severe pre-eclampsia.results:we included 270 women. women in group 3 had significantly elevated rates of severe pre-eclampsia versus those in group 1 and group 2, 52.5% versus 5.1% and 15.4%, respectively, (p<0.01), adjusted odds ratio 4.14 (95% confidence interval, 2.59 to 6.61). kaplan–meier analysis revealed earlier delivery in women with pre-eclampsia in group 3 versus group 1, cox–mantel hazard ratio 2.39 (1.17 to 4.88), log rank p=0.01.conclusion:an abnormal cpr is associated with a higher rate severe pre-eclampsia with delivery at earlier gestational ages than with a normal ua or an abnormal ua, but normal cpr.