Evaluation of the performance of the insulin-like growth factor-binding protein-1/alpha-fetoprotein test in diagnosing ruptured fetal membranes in pregnant women

Objective:the objective of this study was to evaluate the efficacy of igfbp-1/afp (insulin-like growth factor-binding protein-1/alpha-fetoprotein) immunoassay (amnioquick duo+) in diagnosing rupture of membranes (rom).study design:a prospective, observational study was performed in pregnant women with a history of fluid leakage from the vagina. the igfbp-1/afp immunoassay and conventional methods were used to diagnose rom. the obstetricians were blinded to the results of the igfbp-1/afp immunoassay. the diagnosis of rom was finally confirmed by reviewing the medical records after delivery.result:one hundred patients were recruited into this study. the mean gestational age was 37.6 weeks (range 25 to 41 weeks). twenty-six percent were preterm and 74% were at term. igfbp-1/afp immunoassay had a sensitivity of 94.1%, specificity of 87.5%, positive predictive value of 97.5%, negative predictive value of 73.7% and accuracy of 93% in diagnosing rom.conclusion:igfbp-1/afp immunoassay is a rapid immunoassay test for diagnosing rom with a high sensitivity and specificity. this test can be used as an alternative method for diagnosis of rom.