Association of vitamin D binding protein polymorphisms with bronchopulmonary dysplasia: a case–control study of gc globulin and bronchopulmonary dysplasia

Objective:the pathophysiologies of bronchopulmonary dysplasia (bpd) are inflammation, infection, tissue damage, angiogenesis defects and genetic susceptibility. because of the role of the vitamin d binding protein (gc globulin) on these factors, we investigated the relationship between gc globulin polymorphisms and bpd.study design:this case-control study was performed with 160 neonates (⩽32 gestational ages, ⩽1500 g). pcr dna sequence analyses were used for gc gene rs4588 and rs7041 single-nucleotide polymorphisms.result:in the univariate analyses, it was observed that gc2 was the only variant that was protective against bpd (odd ratio (or)=0.47, 95% coinfidence interval (ci)=0.24 to 0.89, p=0.020). in the multivariate analyses, gc2 decreased the risk of disease (or=0.15, 95% ci=0.029 to 0.79, p=0.026) independent of gestational age, birth weight, 5-min appearance, pulse, grimace, activity, and respiration scores, respiratory distress syndrome and sepsis.conclusion:the gc2 variant was, after adjusting for confounders, associated with a decrease in the frequency of bpd. our study adds gc globulin to the list of candidate genes that potentially contribute to the etiology of the disease.