Dynamic thiol-disulfide homeostasis in hyperemesis gravidarum

Objective:to determine serum thiol-disulfide homeostasis in hyperemesis gravidarum.study design:twenty-six pregnant women with hyperemesis gravidarum and 37 healthy pregnant women were included in the study. native thiol, disulfide and total thiol concentrations were measured with a novel automated method.results:serum disulfide levels were 15.68±4.41 μmol l−1 in the hyperemesis gravidarum group and 13.49±2.81 μmol l−1 in the healthy group (p=0.031). native thiol levels were 213.86±26.29 μmol l−1 in the hyperemesis gravidarum group and 232.18±19.21 μmol l−1 in healthy group (p=0.004), and total thiol levels were 245.23±28.58 μmol l−1 in the hyperemesis gravidarum group and 259.17±19.94 μmol l−1 in the healthy group (p=0.038).conclusion:native and total thiol were deficient in the hyperemesis gravidarum group and this deficiency was correlated with the severity of the disease. the thiol-disulfide balance has shifted to the oxidative side. this metabolic disturbance may have a role in the pathogenesis of hyperemesis gravidarum.