The spectrum of onset of acute kidney injury in premature infants less than 30 weeks gestation

Objective:to determine risk factors for acute kidney injury (aki) in preterm infants as a function of time of onset.study design:in this 5 1/2-year, single-center, retrospective study, incidence and timing of aki was determined using modified acute kidney injury network criteria. characteristics of newborns with and without aki were compared by chi square and t-tests. logistic regression was used to examine risk factors for aki as a function of time of onset and potential confounders.result:aki occurred in 30.3% of 357 neonates; 72.2% was stage 1. gestational ages (ga), initial cr, maternal magnesium and volume resuscitation were associated with early aki (days 0 to 1). volume resuscitation, umbilical arterial line and receipt of non-steroidal anti-inflammatory drug (nsaid) for patent ductus arteriosus were associated with intermediate aki (days 2 to 5). ga, steroids for early hypotension, necrotizing enterocolitis and sepsis were associated with late aki (⩾day 6).conclusion:stage 1 aki is a common morbidity in our population. risk factors for aki in our population differed with time of onset.