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Elevated fecal calprotectin levels during necrotizing enterocolitis are associated with activated neutrophils extruding neutrophil extracellular traps
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نویسنده
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MacQueen B C ,Christensen R D ,Yost C C ,Lambert D K ,Baer V L ,Sheffield M J ,Gordon P V ,Cody M J ,Gerday E ,Schlaberg R ,Lowe J ,Shepherd J G
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منبع
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journal of perinatology - 2016 - دوره : 36 - شماره : 10 - صفحه:862 -869
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چکیده
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Objective:neonates with necrotizing enterocolitis (nec) have higher calprotectin levels in stool than do healthy neonates. however, it is not known whether high stool calprotectin at the onset of bowel symptoms identifies neonates who truly have nec vs other bowel disorders.study design:neonates were eligible for this study when an x-ray was ordered to 'rule-out nec'. stool calprotectin was quantified at that time and in a follow-up stool. each episode was later categorized as nec or not nec. the location of calprotectin in the bowel was determined by immunohistochemistry.results:neonates with nec had higher initial and follow-up stool calprotectin levels than did neonates without nec. calprotectin in bowel from neonates with nec was within neutrophil extracellular traps (nets).conclusion:at the onset of signs concerning for nec, fecal calprotectin is likely to be higher in neonates with nec. calprotectin in their stools is exported from neutrophils via nets.
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آدرس
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University of Utah School of Medicine, Department of Pediatrics, Division of Neonatology, USA, University of Utah School of Medicine, Department of Pediatrics, Division of Neonatology, Department of Pediatrics, Division of Hematology/Oncology, USA. Women and Newborn’s Clinical Program, USA, University of Utah School of Medicine, Department of Pediatrics, Division of Neonatology, Program in Molecular Medicine, USA, Women and Newborn’s Clinical Program, USA. McKay-Dee Hospital, USA, Women and Newborn’s Clinical Program, USA. McKay-Dee Hospital, USA, Women and Newborn’s Clinical Program, USA. McKay-Dee Hospital, USA, USA and Sacred Heart Women's and Children's Hospital, USA, University of Utah School of Medicine, Department of Pediatrics, Division of Neonatology, USA, Women and Newborn’s Clinical Program, USA. Utah Valley Regional Medical Center, USA, ARUP Laboratories, USA. University of Utah School of Medicine, Department of Pathology, USA, ARUP Laboratories, USA, Women and Newborn’s Clinical Program, USA. Utah Valley Regional Medical Center, USA
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Authors
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