Prevalence and risk factors of chorioamnionitis in Dhaka, Bangladesh

Objective:to estimate the association between chorioamnionitis, maternal risk factors and birth outcomes.study design:a cross-sectional study of 600 pregnant women was conducted at a maternity center in dhaka from january to october 2011. outcomes included histologic, microbiologic and clinical chorioamnionitis. log-binomial models assessed the association between risk factors and histologic chorioamnionitis (hc).results:of the 552 women with placental specimens, 70 (12.7%) were classified with hc: 46 (65.7%) with and 24 (34.3%) without fetal involvement. hc was associated with non-physician care (relative risk [rr] 2.04, 95% confidence interval [ci] 1.04 to 4.00), home slab or hanging latrine (rr 1.69, 95% ci 1.10 to 2.62), and lack of tetanus toxoid (rr 1.80, 95% ci 1.03 to 3.14). women with fever (rr 2.30, 95% ci 1.18 to 4.50) or discolored amniotic fluid (rr 1.74, 95% ci 1.08 to 2.81) had a higher risk of hc. microbiologic and clinical chorioamnionitis were unreliable hc measures.conclusion:prevalence of hc is high; many cases are not captured by clinical diagnosis or microbiologic cultures.