Sociodemographic and attitudinal predictors of simultaneous and redundant multiple marker and cell-free DNA screening among women aged ⩾35 years

Objective:to identify characteristics associated with undergoing cell-free dna (cfdna) and multiple marker screening (mms) simultaneously or redundantly (after receiving negative results from the first screening test) among women aged ⩾35 years.study design:participants presenting for prenatal testing completed a questionnaire that included measures of pregnancy worry and attitudes toward potential testing outcomes; data on prenatal test use was obtained via medical record review. we used multivariable logistic regression to identify factors associated with redundant or simultaneous screening.results:among 164 participants, 69 (42.1%) had cfdna redundantly (n=51) to, or simultaneously (n=18) with, mms. compared with the 46 mms-negative women who did not undergo further testing, those who underwent redundant or simultaneous cfdna/mms screening were more likely to have annual family incomes >$150 000, to feel having a miscarriage would be worse than having an intellectually disabled child, to desire comprehensive testing for intellectual disability and to have more pregnancy worry.conclusion:providers who counsel patients on prenatal aneuploidy screening tests should explain the appropriate utilization of these screening tests to avoid unnecessary or minimally informative use of multiple tests.