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physiology and pathophysiology of excitation–contraction coupling: the functional role of ryanodine receptor
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نویسنده
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santulli gaetano ,lewis daniel r. ,marks andrew r.
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منبع
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journal of muscle research and cell motility - 2017 - دوره : 38 - شماره : 1 - صفحه:37 -45
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چکیده
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Calcium (ca2+) release from intracellular stores plays a key role in the regulation of skeletal muscle contraction. the type 1 ryanodine receptors (ryr1) is the major ca2+ release channel on the sarcoplasmic reticulum (sr) of myocytes in skeletal muscle and is required for excitation–contraction (e–c) coupling. this article explores the role of ryr1 in skeletal muscle physiology and pathophysiology.
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کلیدواژه
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calcium ,excitation–contraction coupling ,muscular dystrophy ,ryr1 ,skeletal muscle
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آدرس
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columbia university, wu center for molecular cardiology, usa. columbia university medical center, columbia university, college of physicians and surgeons, department of physiology and cellular biophysics, usa, columbia university, wu center for molecular cardiology, usa. columbia university medical center, columbia university, college of physicians and surgeons, department of physiology and cellular biophysics, usa, columbia university, wu center for molecular cardiology, department of medicine, usa. columbia university medical center, columbia university, college of physicians and surgeons, department of physiology and cellular biophysics, usa
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Authors
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