myosin ii sequences for lethocerus indicus

We present the genomic and expressed myosin ii sequences from the giant waterbug, lethocerus indicus. the intron rich gene appears relatively ancient and contains six regions of mutually exclusive exons that are alternatively spliced. alternatively spliced regions be involved in the asymmetric myosin dimer structure known as the interacting heads motif, as well as stabilizing the interacting heads motif within the thick filament. a lack of negative charge in the myosin s2 domain explain why lethocerus thick filaments display a perpendicular interacting heads motif, rather than one folded back to contact s2, as is seen in other thick filament types such as those from tarantula.