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the vital role of atp citrate lyase in chronic diseases
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نویسنده
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khwairakpam amrita devi ,banik kishore ,girisa sosmitha ,shabnam bano ,shakibaei mehdi ,fan lu ,arfuso frank ,monisha javadi ,wang hong ,mao xinliang ,sethi gautam ,kunnumakkara ajaikumar b.
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منبع
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journal of molecular medicine - 2020 - دوره : 98 - شماره : 1 - صفحه:71 -95
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چکیده
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Chronic or non-communicable diseases are the leading cause of death worldwide; they usually result in long-term illnesses and demand long-term care. despite advances in molecular therapeutics, specific biomarkers and targets for the treatment of these diseases are required. the dysregulation of de novo lipogenesis has been found to play an essential role in cell metabolism and is associated with the development and progression of many chronic diseases; this confirms the link between obesity and various chronic diseases. the main enzyme in this pathway—atp-citrate lyase (acly), a lipogenic enzyme—catalyzes the critical reaction linking cellular glucose catabolism and lipogenesis. increasing lines of evidence suggest that the modulation of acly expression correlates with the development and progressions of various chronic diseases such as neurodegenerative diseases, cardiovascular diseases, diabetes, obesity, inflammation, and cancer. recent studies suggest that the inhibition of acly activity modulates the glycolysis and lipogenesis processes and stimulates normal physiological functions. this comprehensive review aimed to critically evaluate the role of acly in the development and progression of different diseases and the effects of its downregulation in the prevention and treatment of these diseases.
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کلیدواژه
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chronic diseases ,atp citrate lyase ,lipogenic enzyme ,fatty acid biosynthesis
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آدرس
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indian institute of technology guwahati, cancer biology laboratory & dbt-aist international laboratory for advanced biomedicine (dailab), department of biosciences & bioengineering, india, indian institute of technology guwahati, cancer biology laboratory & dbt-aist international laboratory for advanced biomedicine (dailab), department of biosciences & bioengineering, india, indian institute of technology guwahati, cancer biology laboratory & dbt-aist international laboratory for advanced biomedicine (dailab), department of biosciences & bioengineering, india, indian institute of technology guwahati, cancer biology laboratory & dbt-aist international laboratory for advanced biomedicine (dailab), department of biosciences & bioengineering, india, ludwig-maximilian-university, institute of anatomy, faculty of medicine, musculoskeletal research group and tumour biology, germany, national university of singapore, yong loo lin school of medicine, department of pharmacology, singapore, curtin university, school of pharmacy and biomedical sciences, curtin health innovation research institute, stem cell and cancer biology laboratory, australia, indian institute of technology guwahati, cancer biology laboratory & dbt-aist international laboratory for advanced biomedicine (dailab), department of biosciences & bioengineering, india, national university of singapore, yong loo lin school of medicine, department of pharmacology, singapore, guangzhou university of chinese medicine, institute of clinical pharmacology, china. soochow university, college of pharmaceutical sciences, department of pharmacology, china, national university of singapore, yong loo lin school of medicine, department of pharmacology, singapore, indian institute of technology guwahati, cancer biology laboratory & dbt-aist international laboratory for advanced biomedicine (dailab), department of biosciences & bioengineering, india
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Authors
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