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the therapeutic potential of aurora kinases targeting in glioblastoma: from preclinical research to translational oncology
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نویسنده
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magalhães taciani de almeida ,sousa graziella ribeiro de ,cruzeiro gustavo alencastro veiga ,tone luiz gonzaga ,valera elvis terci ,borges kleiton silva
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منبع
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journal of molecular medicine - 2020 - دوره : 98 - شماره : 4 - صفحه:495 -512
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چکیده
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Glioblastoma is the most common aggressive primary brain tumor. standard care includes maximal safe surgical resection, radiation, and chemotherapy with temozolomide. however, the impact of this therapeutic approach on patient survival is disappointing and poor outcomes are frequently observed. therefore, new therapeutic targets are needed to treat this potentially deadly tumor. aurora kinases are one of today’s most sought-after classes of therapeutic targets to glioblastoma therapy. they are a family of proteins composed of three members: aurora-a, aurora-b, and aurora-c that play different roles in the cell division through regulation of chromosome segregation. deregulation of these genes has been reported in glioblastoma and a progressive number of studies have shown that inhibition of these proteins could be a promising strategy for the treatment of this tumor. this review discusses the preclinical and early clinical findings on the potential use of the aurora kinases as new targets for the treatment of glioblastoma.
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کلیدواژه
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glioblastoma ,aurora kinases ,aurora kinases inhibitors ,clinical trial
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آدرس
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university of são paulo, ribeirão preto medical school, departments of genetics, brazil, university of são paulo, ribeirão preto medical school, departments of genetics, brazil, university of são paulo, ribeirão preto medical school, departments of pediatrics, brazil, university of são paulo, ribeirão preto medical school, departments of genetics, departments of pediatrics, brazil, university of são paulo, ribeirão preto medical school, departments of pediatrics, brazil, university of são paulo, ribeirão preto medical school, departments of pediatrics, brazil
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Authors
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