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novel therapeutic approaches for treatment of covid-19
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نویسنده
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hossein-khannazer nikoo ,shokoohian bahare ,shpichka anastasia ,aghdaei hamid asadzadeh ,timashev peter ,vosough massoud
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منبع
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journal of molecular medicine - 2020 - دوره : 98 - شماره : 6 - صفحه:789 -803
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چکیده
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To date, there is no licensed treatment or approved vaccine to combat the coronavirus disease of 2019 (covid-19), and the number of new cases and mortality multiplies every day. therefore, it is essential to develop an effective treatment strategy to control the virus spread and prevent the disease. here, we summarized the therapeutic approaches that are used to treat this infection. although it seems that antiviral drugs are effective in improving clinical manifestation, there is no definite treatment protocol. lymphocytopenia, excessive inflammation, and cytokine storm followed by acute respiratory distress syndrome are still unsolved issues causing the severity of this disease. therefore, immune response modulation and inflammation management can be considered as an essential step. there is no doubt that more studies are required to clarify immunopathogenesis and immune response; however, new therapeutic approaches including mesenchymal stromal cell and immune cell therapy showed inspiring results.
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کلیدواژه
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covid-19 ,coronavirus ,therapeutic approaches ,severe acute respiratory syndrome ,acute respiratory distress syndrome ,cell therapy
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آدرس
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shahid beheshti university of medical sciences, school of medicine, gastroenterology and liver diseases research center, research institute for gastroenterology and liver diseases, department of immunology, iran, royan institute for stem cell biology and technology, cell science research center, department of regenerative medicine, iran. tehran university of medical sciences, school of advanced technologies in medicine, department of medical biotechnology, iran, sechenov university, institute for regenerative medicine, russia. lomonosov moscow state university, chemistry department, russia, shahid beheshti university of medical sciences, basic and molecular epidemiology of gastrointestinal disorders research center, research institute for gastroenterology and liver diseases, department of molecular biology, iran, sechenov university, institute for regenerative medicine, russia. lomonosov moscow state university, chemistry department, russia. nn semenov institute of chemical physics, department of polymers and composites, russia. federal research center crystallography and photonics ras, institute of photon technologies, russia, royan institute for stem cell biology and technology, cell science research center, department of regenerative medicine, iran
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Authors
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