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coexpression of foxk1 and vimentin promotes emt, migration, and invasion in gastric cancer cells
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نویسنده
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zhang hui ,wu xiaosheng ,xiao yizhi ,wu liqing ,peng ying ,tang weimei ,liu guangnan ,sun yong ,wang jing ,zhu huiqiong ,liu mengwei ,zhang wenjing ,dai weiyu ,jiang ping ,li aimin ,li guoxin ,xiang li ,liu side ,wang jide
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منبع
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journal of molecular medicine - 2019 - دوره : 97 - شماره : 2 - صفحه:163 -176
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چکیده
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In human gastric cancer (gc), the upregulation of foxk1 and vimentin is frequently observed in cancer cells and correlates with increased malignancy. we report that foxk1 synergizes with vimentin to promote gc invasion and metastasis via the induction of epithelial-mesenchymal transition (emt). we showed that higher expression levels of foxk1 were significantly associated with gc development. foxk1 can physically interact with and stabilize vimentin. moreover, a positive correlation between the expression of foxk1 and vimentin was found in gc cells. higher expression levels of these two proteins were significantly associated with differentiation, lymph node metastasis, ajcc stage, and poorer prognosis. furthermore, the coexpression of foxk1 and vimentin enhances cell metastasis through the induction of emt in gc cells. however, the sirna-mediated repression of vimentin in foxk1-overexpressing cells reversed the emt-like phenotype and reduced gc cell migration and invasion in vitro and in vivo. altogether, our findings suggest that the vimentin-foxk1 axis provides new insights into the molecular mechanisms underlying emt regulation during gc progression and metastasis.
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کلیدواژه
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foxk1 ,vimentin ,gastric cancer ,metastasis ,epithelial-mesenchymal transition
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آدرس
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southern medical university, nanfang hospital, guangdong provincial key laboratory of gastroenterology, department of gastroenterology, china. hexian memorial affiliated hospital of southern medical university, department of gastroenterology, china, southern medical university, nanfang hospital, guangdong provincial key laboratory of gastroenterology, department of gastroenterology, china, southern medical university, nanfang hospital, guangdong provincial key laboratory of gastroenterology, department of gastroenterology, china, southern medical university, nanfang hospital, guangdong provincial key laboratory of gastroenterology, department of gastroenterology, china, southern medical university, nanfang hospital, guangdong provincial key laboratory of gastroenterology, department of gastroenterology, china, southern medical university, nanfang hospital, guangdong provincial key laboratory of gastroenterology, department of gastroenterology, china, southern medical university, nanfang hospital, guangdong provincial key laboratory of gastroenterology, department of gastroenterology, china, southern medical university, nanfang hospital, guangdong provincial key laboratory of gastroenterology, department of gastroenterology, china, southern medical university, nanfang hospital, guangdong provincial key laboratory of gastroenterology, department of gastroenterology, china, southern medical university, nanfang hospital, guangdong provincial key laboratory of gastroenterology, department of gastroenterology, china, southern medical university, nanfang hospital, guangdong provincial key laboratory of gastroenterology, department of gastroenterology, china, kunming university of science and technology, the first people’s hospital of yunnan province, department of medical oncology, china, southern medical university, nanfang hospital, guangdong provincial key laboratory of gastroenterology, department of gastroenterology, china, southern medical university, nanfang hospital, guangdong provincial key laboratory of gastroenterology, department of gastroenterology, china, southern medical university, nanfang hospital, guangdong provincial key laboratory of gastroenterology, department of gastroenterology, china, southern medical university, nanfang hospital, department of general surgery, china, longgang district people’s hospital, department of gastroenterology, china, southern medical university, nanfang hospital, guangdong provincial key laboratory of gastroenterology, department of gastroenterology, china. longgang district people’s hospital, department of gastroenterology, china, southern medical university, nanfang hospital, guangdong provincial key laboratory of gastroenterology, department of gastroenterology, china. longgang district people’s hospital, department of gastroenterology, china
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Authors
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