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   mitochondrial quality control mechanisms as potential therapeutic targets in sepsis-induced multiple organ failure  
   
نویسنده wu you ,yao yong-ming ,lu zhong-qiu
منبع journal of molecular medicine - 2019 - دوره : 97 - شماره : 4 - صفحه:451 -462
چکیده    Sepsis is a dysregulated response to severe infection characterized by life-threatening organ failure and is the leading cause of mortality worldwide. multiple organ failure is the central characteristic of sepsis and is associated with poor outcome of septic patients. ultrastructural damage to the mitochondria and mitochondrial dysfunction are reported in sepsis. mitochondrial dysfunction with subsequent atp deficiency, excessive reactive oxygen species (ros) release, and cytochrome c release are all considered to contribute to organ failure. consistent mitochondrial dysfunction leads to reduced mitochondrial quality control capacity, which eliminates dysfunctional and superfluous mitochondria to maintain mitochondrial homeostasis. mitochondrial quality is controlled through a series of processes including mitochondrial biogenesis, mitochondrial dynamics, mitophagy, and transport processes. several studies have indicated that multiple organ failure is ameliorated by restoring mitochondrial quality control mechanisms and is further amplified by defective quality control mechanisms. this review will focus on advances concerning potential mechanisms in regulating mitochondrial quality control and impacts of mitochondrial quality control on the progression of sepsis.
کلیدواژه sepsis ,mitochondrial dysfunction ,mitochondrial biogenesis ,mitophagy ,mitochondrial dynamics
آدرس the first affiliated hospital of wenzhou medical university, emergency department, wenzhou municipal key laboratory of emergency, people’s republic of china, the first affiliated hospital of wenzhou medical university, emergency department, people’s republic of china. first hospital affiliated to the chinese pla general hospital, trauma research center, people’s republic of china, the first affiliated hospital of wenzhou medical university, emergency department, wenzhou municipal key laboratory of emergency, people’s republic of china. wenzhou medical university, college of nursing, people’s republic of china
 
     
   
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