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sphingosine-coating of plastic surfaces prevents ventilator-associated pneumonia
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نویسنده
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seitz aaron p. ,schumacher fabian ,baker jennifer ,soddemann matthias ,wilker barbara ,caldwell charles c. ,gobble ryan m. ,kamler markus ,becker katrin anne ,beck sascha ,kleuser burkhard ,edwards michael j. ,gulbins erich
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منبع
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journal of molecular medicine - 2019 - دوره : 97 - شماره : 8 - صفحه:1195 -1211
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چکیده
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Ventilator-associated pneumonia (vap) is a major cause of morbidity and mortality in critically ill patients. here, we employed the broad antibacterial effects of sphingosine to prevent vap by developing a novel method of coating surfaces of endotracheal tubes with sphingosine and sphingosine analogs. sphingosine and phytosphingosine coatings of endotracheal tubes prevent adherence and mediate killing of pseudomonas aeruginosa, acinetobacter baumannii, and staphylococcus aureus, even in biofilms. most importantly, sphingosine-coating of endotracheal tubes also prevented p. aeruginosa and s. aureus pneumonia in vivo. coating of the tubes with sphingosine was stable, without obvious side effects on tracheal epithelial cells and did not induce inflammation. in summary, we describe a novel method to coat plastic surfaces and provide evidence for the application of sphingosine and phytosphingosine as novel antimicrobial coatings to prevent bacterial adherence and induce killing of pathogens on the surface of endotracheal tubes with potential to prevent biofilm formation and vap.
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کلیدواژه
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coating ,plastic surfaces ,sphingosine ,ventilation ,acinetobacter baumannii ,pseudomonas aeruginosa ,staphylococcus aureus
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آدرس
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university of cincinnati, college of medicine, department of surgery, usa, university of potsdam, institute of nutritional science, department of toxicology, germany. university hospital essen, university of duisburg-essen, department of molecular biology, germany, university of cincinnati, college of medicine, department of surgery, usa, university hospital essen, university of duisburg-essen, department of molecular biology, germany, university hospital essen, university of duisburg-essen, department of molecular biology, germany, university of cincinnati, college of medicine, department of surgery, usa. shriners hospital for children, division of research, usa, university of cincinnati, college of medicine, department of surgery, usa, university hospital essen, university of duisburg-essen, germany, university hospital essen, university of duisburg-essen, department of molecular biology, germany, university hospital essen, university of duisburg-essen, germany, university of potsdam, institute of nutritional science, department of toxicology, germany, university of cincinnati, college of medicine, department of surgery, usa, university of cincinnati, college of medicine, department of surgery, usa. university hospital essen, university of duisburg-essen, department of molecular biology, germany
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Authors
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