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The regulation of skeletal muscle fiber-type composition by betaine is associated with NFATc1/MyoD
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نویسنده
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Du Jingjing ,Shen Linyuan ,Zhang Peiwen ,Tan Zhendong ,Cheng Xiao ,Luo Jia ,Zhao Xue ,Yang Qiong ,Gu Hao ,Jiang An’an ,Ma Jideng ,Tang Qianzi ,Jin Long ,Shuai Surong ,Li Mingzhou ,Jiang Yanzhi ,Tang Guoqing ,Bai Lin ,Li Xuewei ,Wang Jinyong ,Zhang Shunhua ,Zhu Li
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منبع
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journal of molecular medicine - 2018 - دوره : 96 - شماره : 7 - صفحه:685 -700
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چکیده
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Increasing evidence indicates that muscular dysfunction or alterations in skeletal muscle fiber-type composition not only are involved in muscle metabolism and function but also can limit functional capacity. therefore, understanding the mechanisms regulating key events during skeletal myogenesis is necessary. betaine is a naturally occurring component of commonly eaten foods. here, we showed that 10 mm betaine supplementation in vitro significantly repressed myoblast proliferation and enhanced myoblast differentiation. this effect can be mediated by regulation of mir-29b-3p. further analysis showed that betaine supplementation in vitro regulated skeletal muscle fiber-type composition through the induction of nfatc1 and the negative regulation of myod expression. furthermore, mice fed with 10 mm betaine in water for 133 days showed no impairment in overall health. consistently, betaine supplementation increased muscle mass, promoted muscle formation, and modulated the ratio of fiber types in skeletal muscle in vivo. these findings shed light on the diverse biological functions of betaine and indicate that betaine supplementation lead to new therapies for diseases such as muscular dystrophy or other diseases related to muscle dysfunction.
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کلیدواژه
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Betaine ,Proliferation ,Differentiation ,Muscle fiber type ,NFATc1 ,MyoD
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آدرس
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Sichuan Agricultural University, China, Sichuan Agricultural University, China, Sichuan Agricultural University, China, Sichuan Agricultural University, China, Sichuan Agricultural University, China, Sichuan Agricultural University, China, Sichuan Agricultural University, China, Chengdu Agricultural College, Department of Animal Husbandry and Veterinary Medicine, China, Sichuan Agricultural University, China, Sichuan Agricultural University, China, Sichuan Agricultural University, China, Sichuan Agricultural University, China, Sichuan Agricultural University, China, Sichuan Agricultural University, China, Sichuan Agricultural University, China, Sichuan Agricultural University, China, Sichuan Agricultural University, China, Sichuan Agricultural University, China, Sichuan Agricultural University, China, Chongqing Academy of Animal Sciences, China, Sichuan Agricultural University, China, Sichuan Agricultural University, China
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Authors
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