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   COMP-angiopoietin-1 ameliorates inflammation-induced lymphangiogenesis in dextran sulfate sodium (DSS)-induced colitis model  
   
نویسنده Lee Ae Sin ,Sung Mi Jeong ,Kim Won ,Jung Yu Jin
منبع journal of molecular medicine - 2018 - دوره : 96 - شماره : 5 - صفحه:459 -467
چکیده    Alterations in the intestinal lymphatic network are pathological processes as related to inflammatory bowel disease (ibd). in this study, we demonstrated that reduction in inflammation-induced lymphangiogenesis ameliorates experimental acute colitis. a soluble and stable angiopoietin-1 (ang1) variant, comp-ang1, possesses anti-inflammatory and angiogenic effects. we investigated the effects of comp-ang1 on an experimental colonic inflammation model. experimental colitis was induced in mice by administering 3% dextran sulfate sodium (dss) via drinking water. we determined body weight, disease activity indices, histopathological scores, lymphatic density, anti-er-hr3 staining, and the expression of members of the vascular endothelial growth factor (vegf) family and various inflammatory cytokines in the mice. the density of lymphatic vessel endothelial hyaluronan receptor 1 (lyve-1) and vegfr-3-positive lymphatic vessels increased in mice with dss-induced colitis. we observed that comp-ang1-treated mice showed less weight loss, fewer clinical signs of colitis, and longer colons than ade-dss-treated mice. comp-ang1 also significantly reduced the density of lyve-1-positive lymphatic vessels and the disruption of colonic architecture that is normally associated with colitis and repressed the immunoregulatory response. further, comp-ang1 treatment reduced both m1 and m2 macrophage infiltration into the inflamed colon, which involved inhibition of vegf-c and d expression. thus, comp-ang1, which acts by reducing inflammation-induced lymphangiogenesis, be used as a novel therapeutic for the treatment of ibd and other inflammatory diseases.
کلیدواژه Angiopoietin-1 ,Lymphangiogenesis ,Inflammation ,Macrophages ,Colitis ,VEGF
آدرس Korea Food Research Institute, South Korea, Korea Food Research Institute, South Korea, Chonbuk National University Medical School, Department of Internal Medicine, Division of Nephrology, South Korea. Research Institute of Clinical Medicine of Chonbuk National University, Biomedical Research Institute of Chonbuk National University Hospital, South Korea, Chonbuk National University Medical School, Department of Internal Medicine, Division of Nephrology, South Korea
 
     
   
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