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Expression of IL-17F is associated with non-pathogenic Th17 cells
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نویسنده
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Wanke Florian ,Tang Yilang ,Gronke Konrad ,Klebow Sabrina ,Moos Sonja ,Hauptmann Judith ,Shanmugavadivu Arthi ,Regen Tommy ,Mufazalov Ilgiz A. ,Gabriel Lauren A. ,Reißig Sonja ,Diefenbach Andreas ,Kurschus Florian C. ,Waisman Ari
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منبع
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journal of molecular medicine - 2018 - دوره : 96 - شماره : 8 - صفحه:819 -829
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چکیده
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Il-17a and il-17f share the highest sequence homology of the il-17 family and signal via the same il-17ra/rc receptor heterodimer. to better explore the expression of these two cytokines, we used a double reporter mouse strain (il-17dr mice), where il-17a expressing cells are marked by enhanced green fluorescent protein (egfp) while red fluorescence protein (rfp) reports the expression of il-17f. in steady state, we found that th17 and γδ t cells only expressed il-17a, while il-17f expression was restricted to cd8 t cells (tc17) and innate lymphoid cells (ilc type 3) of the gut. in experimental autoimmune encephalomyelitis, the vast majority of cns-infiltrating th17 cells expressed il-17a but not il-17f. in contrast, anti-cd3-induced, tgf-β-driven th17 cells in the gut expressed both of these il-17 cytokines. in line with this, in vitro differentiation of th17 cells in the presence of il-1β led primarily to il-17a expressing t cells, while tgf-β induced il-17f co-expressing th17 cells. our results suggest that expression of il-17f is associated with non-pathogenic t cells, pointing to a differential function of il-17a versus il-17f.
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کلیدواژه
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IL-17F ,Th17 cells ,IL-17A ,EAE ,Reporter mice
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آدرس
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University Medical Center of the Johannes Gutenberg University Mainz, Germany. Immunology, Switzerland, University Medical Center of the Johannes Gutenberg University Mainz, Germany, University Medical Center of the Johannes Gutenberg University Mainz, Germany. Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Germany, University Medical Center of the Johannes Gutenberg University Mainz, Germany, University Medical Center of the Johannes Gutenberg University Mainz, Germany, University Medical Center of the Johannes Gutenberg University Mainz, Germany, University Medical Center of the Johannes Gutenberg University Mainz, Germany, University Medical Center of the Johannes Gutenberg University Mainz, Germany, University Medical Center of the Johannes Gutenberg University Mainz, Germany, University Medical Center of the Johannes Gutenberg University Mainz, Germany, University Medical Center of the Johannes Gutenberg University Mainz, Germany, University Medical Center of the Johannes Gutenberg University Mainz, Germany. Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Germany, University Medical Center of the Johannes Gutenberg University Mainz, Germany. Heidelberg University Hospital, Department of Dermatology, Germany, University Medical Center of the Johannes Gutenberg University Mainz, Germany
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Authors
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