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Re-educating immunity in respiratory allergies: the potential for hematopoietic stem cell-mediated gene therapy
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نویسنده
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Brooks Jeremy F. ,Davies Janet M. ,Wells James W. ,Steptoe Raymond J.
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منبع
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journal of molecular medicine - 2018 - دوره : 96 - شماره : 1 - صفحه:21 -30
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چکیده
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Respiratory allergies represent a significant disease burden worldwide affecting up to 300 million people globally. medication and avoidance of known triggers do not address the underlying pathology. traditional immunotherapies for allergy aim to reinstate immune homeostasis but require years of treatment and have poor long-term efficacy. novel approaches, such as gene-engineered hematopoietic stem cell transplantation, induce profound antigen-specific tolerance in autoimmunity. recent evidence shows this approach also have therapeutic utility for allergy. here, we review the mechanisms of antigen-specific tolerance and the potential of stem cell-mediated gene therapy to induce tolerance in allergic respiratory diseases.
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کلیدواژه
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Allergy ,Autoimmunity ,Tolerance ,Gene therapy
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آدرس
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University of Queensland, University of Queensland Diamantina Institute, Australia, Queensland University of Technology, Australia. Metro North Hospital and Health Service, Australia, University of Queensland, University of Queensland Diamantina Institute, Australia, University of Queensland, University of Queensland Diamantina Institute, Australia
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Authors
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