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MicroRNA let-7g cooperates with interferon/ribavirin to repress hepatitis C virus replication
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نویسنده
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Chou Wen-Wen ,Huang Chung-Feng ,Yeh Ming-Lun ,Tsai Yi-Shan ,Hsieh Ming-Yen ,Huang Ching-I ,Huang Jee-Fu ,Tsai Pei-Chien ,Hsi Edward ,Juo Suh-Hang Hank ,Tsai Wei-Lun ,Chuang Wan-Long ,Yu Ming-Lung ,Dai Chia-Yen
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منبع
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journal of molecular medicine - 2016 - دوره : 94 - شماره : 3 - صفحه:311 -320
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چکیده
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Micrornas (mirna) have been implicated in hcv infection. the present study analyzed the effects of let-7g on hcv infection in vitro, in clinical tissue and serum samples. here, we show that the expression of let-7g in serum and liver tissue is significantly higher in patients with sustained virologic response (svr). we show that interferon (ifn)/ribavirin (rbv) induces let-7g expression through p38/ap-1 signaling. overexpression of let-7g reduced hcv gene or core protein level and inhibited the hcv viral load. the let-7g and ifn/rbv have additively inhibitory effect on hcv replication. these data implicate let-7g as a new therapeutic drug to additively cooperate with ifn/rbv to repress hcv replication.
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کلیدواژه
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HCV ,JFH ,Let-7g ,IFN ,RBV
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آدرس
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Kaohsiung Medical University Hospital, Hepatobiliary Division, Department of Internal Medicine, Taiwan, Kaohsiung Medical University Hospital, Hepatobiliary Division, Department of Internal Medicine, Taiwan. Kaohsiung Medical University, Taiwan, Kaohsiung Medical University Hospital, Hepatobiliary Division, Department of Internal Medicine, Taiwan. Kaohsiung Medical University, Taiwan, Kaohsiung Medical University Hospital, Hepatobiliary Division, Department of Internal Medicine, Taiwan, Kaohsiung Medical University Hospital, Hepatobiliary Division, Department of Internal Medicine, Taiwan, Kaohsiung Medical University Hospital, Hepatobiliary Division, Department of Internal Medicine, Taiwan, Kaohsiung Medical University Hospital, Hepatobiliary Division, Department of Internal Medicine, Taiwan. Kaohsiung Medical University, Taiwan, Kaohsiung Medical University Hospital, Hepatobiliary Division, Department of Internal Medicine, Taiwan, Kaohsiung Medical University Hospital, Department of Medical Research, Taiwan. Kaohsiung Medical University, Department of Genome Medicine, Taiwan, Kaohsiung Medical University Hospital, Department of Medical Research, Taiwan. Kaohsiung Medical University, Department of Genome Medicine, Taiwan, Kaohsiung Veterans General Hospital, Division of Gastroenterology, Department of Internal Medicine, Taiwan. National Yang Ming University, Taiwan, Kaohsiung Medical University, Taiwan. Kaohsiung Medical University Hospital, Hepatobiliary Division, Department of Internal Medicine, Taiwan, Kaohsiung Medical University Hospital, Hepatobiliary Division, Department of Internal Medicine, Taiwan. Kaohsiung Medical University, Taiwan, Kaohsiung Medical University Hospital, Hepatobiliary Division, Department of Internal Medicine, Department of Preventive Medicine, Taiwan. Kaohsiung Medical University, Taiwan
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Authors
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