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Biological and pathological activities of interleukin-22
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نویسنده
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Lanfranca Mirna Perusina ,Lin Yanwei ,Fang Jingyuan ,Zou Weiping ,Frankel Timothy
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منبع
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journal of molecular medicine - 2016 - دوره : 94 - شماره : 5 - صفحه:523 -534
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چکیده
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Interleukin (il)-22, a member of the il-10 family, is a cytokine secreted by several types of immune cells including il-22+cd4+ t cells (th22) and il-22 expressing innate leukocytes (ilc22). recent studies have demonstrated that il-22 is a key component in mucosal barrier defense, tissue repair, epithelial cell survival, and proliferation. furthermore, accumulating evidence has defined both protective and pathogenic properties of il-22 in a number of conditions including autoimmune disease, infection, and malignancy. in this review, we summarize the expression and signaling pathway and functional characteristics of the il-22 and il-22 receptor axis in physiological and pathological scenarios and discuss the potential to target il-22 signaling to treat human diseases.
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کلیدواژه
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IL-22 ,Th22 ,ILC22 ,Cancer ,T cell ,Cancer ,Autoimmune ,Infection ,IL-22R ,IL-22BP
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آدرس
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University of Michigan School of Medicine, Department of Surgery, USA, University of Michigan School of Medicine, Department of Surgery, USA. Shanghai Jiao-Tong University, Division of Gastroenterology and Hepatology, China, Shanghai Jiao-Tong University, Division of Gastroenterology and Hepatology, China, University of Michigan, Graduate Programs in Immunology and Tumor Biology, USA. University of Michigan School of Medicine, Department of Surgery, USA. University of Michigan Comprehensive Cancer Center, University of Michigan, USA, University of Michigan Comprehensive Cancer Center, University of Michigan, USA. University of Michigan School of Medicine, Department of Surgery, USA
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Authors
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