sulfonyl-containing boronate caps for optimization of biological properties of 99m tc(iii) radiotracers [ 99m tccl(cdo)(cdoh) 2 b-r] (cdoh 2 = cyclohexanedione dioxime)

In this study, different boronate caps were used to optimize biodistribution properties of radiotracers [ 99m tccl(cdo)(cdoh) 2 b-r] (1, r = 3s; 2, r = 3sp; 3, r = 3ms; 4, r = 3dms; 5, r = 3msb; 6, r = 3mms; 7, r = 3msa; 8, r = 3dmsa; 9, r = 4s; 10, r = 4ms; 11, r = 4msb). among the 11 new 99m tc radiotracers, 2 shows the most promising characteristics of an optimal heart imaging agent. its initial heart uptake is close to that of 99m tc-teboroxime, but its heart retention time is significantly longer. its heart/liver, heart/lung, and heart/muscle ratios are also better than those of 99m tc-teboroxime. the spect image quality with 2 in sd rats is better than that with 99m tc-teboroxime. the high initial heart uptake, long heart retention, and high heart/background ratios make 2 an excellent spect radiotracer for mpi.