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   In vitro diagnosis of immediate allergic reactions to drugs: An update  
   
نویسنده mayorga c. ,sanz m.l. ,gamboa p.m. ,garcía b.e.
منبع journal of investigational allergology and clinical immunology - 2010 - دوره : 20 - شماره : 2 - صفحه:103 -109
چکیده    Evaluation of allergic reactions to drugs is difficult because of the poor sensitivity of in vivo tests,which makes controlled administration of the drug necessary to confirm the diagnosis. in vitro tests are important in order to avoid the risks of in vivo testing. in the present review,we describe the different methods for detecting immunoglobulin (ig) e antibodies that are specific to drugs involved in the development of type i (immediate) reactions. the 2 main in vitro methods are immunoassays and the basophil activation test,both of which have sufficient sensitivity and specificity for the detection of specific ige antibodies,although with a limited number of drugs,and they have proven complementary to in vivo methods. we show the importance of the allergological workup of the patient within less than 1 year from the occurrence of the allergic reaction in order to obtain positive results in both in vivo and in vitro tests. © 2010 esmon publicidad.
کلیدواژه Allergy; Basophil activation test; Drug; IgE; Immunoassay; In vitro test; In vivo test
آدرس research laboratory,fundación imabis - carlos haya hospital,malaga, Spain, departament of clinical allergology and immunology,university of navarra,pamplona, Spain, allergology service,hospital de basurto,bilbao, Spain, allergology service,hospital virgen del camino,pamplona, Spain
 
     
   
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