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Study of cross-reactivity between proton pump inhibitors
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نویسنده
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elfau m.t.s. ,sotillos m.g. ,clavería l.f. ,arazuri n.s. ,ballarín s.m. ,sanz c.c.
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منبع
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journal of investigational allergology and clinical immunology - 2010 - دوره : 20 - شماره : 2 - صفحه:157 -161
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چکیده
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Several studies have demonstrated different cross-reactivity patterns between proton pump inhibitors (ppis). the aim of this study was to investigate cross-reactivity between commercially available ppis and establish a procedure for performing cutaneous tests for verifying ppi allergy. we performed skin prick and intradermal tests with all commercially available ppis in 5 patients with clinical allergy to omeprazole and observed positive results in all patients. we report 5 cases of immunoglobulin (ig) e-mediated allergy to omeprazole and document cross-reactivity by skin testing between all the ppis studied. we also found that the probability of confirming an ige-mediated mechanism with skin tests decreases with time. finally,we propose a hypothesis that could explain the different ppi cross-reactivity patterns reported. © 2010 esmon publicidad.
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کلیدواژه
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Esomeprazole; Lansoprazole; Omeprazole; Pantoprazole; Proton pump inhibitors; Rabeprazole
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آدرس
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hospital clínico universitario lozano blesa,zaragoza, Spain, hospital clínico universitario lozano blesa,zaragoza, Spain, hospital clínico universitario lozano blesa,zaragoza, Spain, hospital clínico universitario lozano blesa,zaragoza, Spain, hospital clínico universitario lozano blesa,zaragoza, Spain, hospital clínico universitario lozano blesa,zaragoza, Spain
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Authors
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