Study of cross-reactivity between proton pump inhibitors

Several studies have demonstrated different cross-reactivity patterns between proton pump inhibitors (ppis). the aim of this study was to investigate cross-reactivity between commercially available ppis and establish a procedure for performing cutaneous tests for verifying ppi allergy. we performed skin prick and intradermal tests with all commercially available ppis in 5 patients with clinical allergy to omeprazole and observed positive results in all patients. we report 5 cases of immunoglobulin (ig) e-mediated allergy to omeprazole and document cross-reactivity by skin testing between all the ppis studied. we also found that the probability of confirming an ige-mediated mechanism with skin tests decreases with time. finally,we propose a hypothesis that could explain the different ppi cross-reactivity patterns reported. © 2010 esmon publicidad.