Sublingual immunotherapy in peach allergy: Monitoring molecular sensitizations and reactivity to apple fruit and Platanus pollen

Background: peach allergy is prevalent,persistent,and potentially severe and as such is a target for immunotherapy. our aims were to evaluate the profile of sensitization to rosaceae allergens and the effects of sublingual peach immunotherapy on immunoglobulin (ig) e levels to these allergens,to monitor for neosensitizations,and to check if this treatment modifi ed other rosaceae fruit and pollen-related sensitizations. methods: a double-blind placebo-controlled trial was conducted on 56 peach-allergic patients who received,sublingually,a standardized peach extract quantified in mass units of pru p 3,or placebo for 6 months. ige to recombinant (r) mal d 1,rmal d 4,rpru p 3,and natural (n) art v 3 and skin prick test (spt) reactivity to platanus pollen and apple extracts evaluated before treatment (t0),after 1 month (t1) and after and 6 months (t6) were recorded. results: in total,18.5% of patients recognized rmal d 1,83.3%,rpru p 3,24.1%,rmal d 4,and 25.9% nart v 3. ige to pru p 3 rose from t0 to t1 in both the active group (p=.003) and the placebo group (p=.022),and remained elevated at t6 in the active group (p=.001) ge to other purifi ed allergens did not change signifi cantly and no relevant neosensitizations were detected. spt reactions to peach decreased from t0 to t6 in the active group (p<0.05). reactivity to peach (t1 and t6) and apple (t6) was lower in the active group than in the control group. conclusions: the main allergen was pru p 3. changes in rpru p 3 ige levels and in peach and apple extract spt were induced by sublingual immunotherapy. © 2010 esmon publicidad.