Consensus statement on the diagnosis,management,and treatment of angioedema mediated by bradykinin. Part I. classification,epidemiology,pathophysiology,genetics,clinical symptoms,and diagnosis

Background: there are no spanish guidelines or consensus statement on bradykinin-induced angioedema. aim: to review the pathophysiology,genetics,and clinical symptoms of the different types of bradykinin-induced angioedema and to draft a consensus statement in light of currently available scientific evidence and the experience of experts. this statement will serve as a guideline to health professionals. methods: the consensus was led by the spanish study group on bradykinin-induced angioedema (sgba),a working group of the spanish society of allergology and clinical immunology. a review was conducted of scientific papers on different types of bradykinin-induced angioedema (hereditary and acquired angioedema due to c1 inhibitor deficiency,hereditary angioedema related to estrogens,angioedema induced by angiotensin-converting enzyme inhibitors). several discussion meetings of the sgba were held in madrid to reach the consensus. results: the pathophysiology,genetics,and clinical symptoms of the different types of angioedema are reviewed. diagnostic approaches are discussed and the consensus reached is described. conclusions: a review of bradykinin-induced angioedema and a consensus on diagnosis are presented. © 2011 esmon publicidad.