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Variations in the STK10 gene and possible associations with aspirin-intolerant asthma in a Korean population
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نویسنده
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kim j.-h. ,park b.-l. ,cheong h.s. ,pasaje c.f.a. ,bae j.s. ,park j.s. ,jang a.s. ,uh s.-t. ,choi j.-s. ,kim y.-h. ,kim m.-k. ,choi i.s. ,cho s.h. ,choi b.w. ,koh i.s. ,park c.-s. ,shin h.d.
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منبع
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journal of investigational allergology and clinical immunology - 2011 - دوره : 21 - شماره : 5 - صفحه:378 -388
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چکیده
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Background and objective: lymphocyte-oriented kinase deficiency encoded by the serine/threonine kinase 10 (stk10) gene correlates with the intracellular adhesion molecule 1 (icam-1)/lymphocyte function associated antigen 1 (lfa-1) complex in aspirin hypersensitivity. this study investigated the association between single nucleotide polymorphisms (snps) of stk10 and aspirin-intolerant asthma (aia). methods: a total of 54 snps were genotyped in 163 aia patients and 429 aspirin-tolerant asthma (ata) controls. results: logistic regression revealed that a synonymous variant (rs2306961g>a) had the most significant association with aia (p=.008 under the codominant model; p=.004 under the dominant model),suggesting that tissue-specific codon usage between lys_ttt and lys_ctt could play a role in regulating expression of stk10 in airway epithelium. haplotype analysis revealed that 4 haplotypes,including stk10_bl4-ht1,which is unique to rs2306961g>a,were significantly associated with aspirin hypersensitivity in asthmatics (p<.05). conclusions: although replications in independent cohorts and further functional evaluations are needed,our preliminary findings suggest that stk10 polymorphisms might be susceptible genetic markers of aia and that gene expression could be mediated by tissue-specific codon usage.
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کلیدواژه
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Aspirin-intolerant asthma; Haplotype; Single-nucleotide polymorphism; STK10
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آدرس
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department of life science,sogang university,seoul,121-742, South Korea, department of genetic epidemiology,snp genetics,inc.,seoul, South Korea, department of genetic epidemiology,snp genetics,inc.,seoul, South Korea, department of life science,sogang university,seoul,121-742, South Korea, department of life science,sogang university,seoul,121-742, South Korea, division of allergy and respiratory medicine,soonchunhyang university seoul hospital,seoul, South Korea, division of allergy and respiratory medicine,soonchunhyang university seoul hospital,seoul, South Korea, division of allergy and respiratory medicine,soonchunhyang university seoul hospital,seoul, South Korea, division of allergy and respiratory disease,soonchunhyang university cheonan hospital,cheonan, South Korea, division of allergy and respiratory disease,soonchunhyang university cheonan hospital,cheonan, South Korea, division of internal medicine,chungbuk national university,cheongju, South Korea, department of allergy,chonnam national university,gwangju, South Korea, department of internal medicine and institute of allergy and clinical immunology,seoul national university,seoul, South Korea, department of internal medicine,chung-ang university yongsan hospital,seoul, South Korea, department of physiology,college of medicine,han yang university,seoul, South Korea, division of allergy and respiratory medicine,soonchunhyang university seoul hospital,seoul, South Korea, department of life science,sogang university,seoul,121-742,south korea,department of genetic epidemiology,snp genetics,inc.,seoul, South Korea
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Authors
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