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Genetic variant rs4982958 at 14q11.2 is associated with allergic rhinitis in a chinese han population running title: 14q11.2 is a susceptibility locus for allergic rhinitis
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نویسنده
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tang x.f. ,tang h.y. ,sun l.d. ,xiao f.l. ,zhang z. ,li y. ,zuo x.b. ,zhou f.s. ,yang k.l. ,fang p. ,liu y.h. ,du w.d. ,yang s. ,duan m.-l. ,zhang x.-j.
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منبع
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journal of investigational allergology and clinical immunology - 2012 - دوره : 22 - شماره : 1 - صفحه:55 -62
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چکیده
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Background: allergic rhinitis (ar) is one of the most common diseases caused by the combined effects of intrinsic factors (susceptibility genes and immunological status) and the external environment. analyses of ascendant family history of atopic disease suggest that ar and atopic dermatitis might share a similar genetic background. objective: to conduct a case-control study in a chinese han population to evaluate the potential influence of single nucleotide polymorphisms (snps) at flg,5q22.1,11q13.5,14q11.2 and 20q13.33 on ar. methods: ten snps-rs11204971 and rs3126085 at flg,rs10067777,rs7701890,rs13360927,and rs13361382 at 5q22.1,rs6010620 at 20q13.33,rs7936562 and rs7124842 at 11q13.5,and rs4982958 at 14q11.2 were genotyped in 363 cases and 668 controls using the sequenom massarray system. data were analyzed with plink 1.07 software. results: the t allele of rs4982958 at 14q11.2 was observed to be significantly associated with ar (p=.002,or=0.73,p bonferroni=.02). genotypebased association testing revealed that the recessive model might provide the best fit for rs4982958 (p bonferroni=.01). in subphenotype analyses,the rs4982958 t allele was also significantly associated with persistent ar (p =.01) and more than 2 positive skin prick tests (p=.038). conclusion: we identified a novel susceptibility locus 14q11.2 for ar that might bear candidate genes conferring susceptibility to ar and affecting disease phenotypes. © 2012 esmon publicidad.
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کلیدواژه
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14q11.2; Allergic rhinitis; Genetic; Polymorphism; Susceptibility
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آدرس
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institute of dermatology and department of dermatology,no.1 hospital,anhui medical university,hefei,anhui,china,key laboratory of dermatology,anhui medical university,ministry of education,china,hefei,anhui,china,state key laboratory incubation base of dermatology,anhui medical university,81 meishan road,hefei,anhui 230032, China, institute of dermatology and department of dermatology,no.1 hospital,anhui medical university,hefei,anhui,china,key laboratory of dermatology,anhui medical university,ministry of education,china,hefei,anhui,china,state key laboratory incubation base of dermatology,anhui medical university,81 meishan road,hefei,anhui 230032, China, institute of dermatology and department of dermatology,no.1 hospital,anhui medical university,hefei,anhui,china,key laboratory of dermatology,anhui medical university,ministry of education,china,hefei,anhui,china,state key laboratory incubation base of dermatology,anhui medical university,81 meishan road,hefei,anhui 230032, China, institute of dermatology and department of dermatology,no.1 hospital,anhui medical university,hefei,anhui,china,key laboratory of dermatology,anhui medical university,ministry of education,china,hefei,anhui,china,state key laboratory incubation base of dermatology,anhui medical university,81 meishan road,hefei,anhui 230032, China, institute of dermatology and department of dermatology,no.1 hospital,anhui medical university,hefei,anhui,china,key laboratory of dermatology,anhui medical university,ministry of education,china,hefei,anhui,china,state key laboratory incubation base of dermatology,anhui medical university,81 meishan road,hefei,anhui 230032, China, institute of dermatology and department of dermatology,no.1 hospital,anhui medical university,hefei,anhui,china,key laboratory of dermatology,anhui medical university,ministry of education,china,hefei,anhui,china,state key laboratory incubation base of dermatology,anhui medical university,81 meishan road,hefei,anhui 230032, China, key laboratory of dermatology,anhui medical university,ministry of education,china,hefei,anhui,china,state key laboratory incubation base of dermatology,anhui medical university,81 meishan road,hefei,anhui 230032, China, key laboratory of dermatology,anhui medical university,ministry of education,china,hefei,anhui,china,state key laboratory incubation base of dermatology,anhui medical university,81 meishan road,hefei,anhui 230032, China, department of otolaryngology head and neck,no.1 hospital,anhui medical university,hefei,anhui, China, department of otolaryngology head and neck,no.1 hospital,anhui medical university,hefei,anhui, China, department of otolaryngology head and neck,no.1 hospital,anhui medical university,hefei,anhui, China, key laboratory of dermatology,anhui medical university,ministry of education,china,hefei,anhui,china,state key laboratory incubation base of dermatology,anhui medical university,81 meishan road,hefei,anhui 230032, China, institute of dermatology and department of dermatology,no.1 hospital,anhui medical university,hefei,anhui,china,key laboratory of dermatology,anhui medical university,ministry of education,china,hefei,anhui,china,state key laboratory incubation base of dermatology,anhui medical university,81 meishan road,hefei,anhui 230032, China, department of otolaryngology head and neck,no.1 hospital,anhui medical university,hefei,anhui,china,department of clinical science,intervention and technology karolinska university hospital,171 76 stockholm, Sweden, institute of dermatology and department of dermatology,no.1 hospital,anhui medical university,hefei,anhui,china,key laboratory of dermatology,anhui medical university,ministry of education,china,hefei,anhui,china,state key laboratory incubation base of dermatology,anhui medical university,81 meishan road,hefei,anhui 230032, China
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