Association between polymorphisms in IL17F and male asthma in a Chinese population

Background and objectives: interleukin (il) 17f is a marker of type 17 helper t cells and has a proinflammatory role in asthma. the aim of the present study was to assess the possible association between asthma and polymorphisms in the il17f gene in a chinese population. methods: a total of 318 asthmatic patients and 352 nonasthmatic controls were recruited. two single-nucleotide polymorphisms in il17f (rs763780 and rs13209590) were detected using genomelab snpstream. logistic regression methods were used to analyze data. results: a significantly lower frequency of the c allele in rs763780 was observed in the control group (p=.0148). the rs763780 tc heterozygote was associated with an increased risk of asthma,and a similar trend was observed assuming a codominant genotype effect (adjusted or,1.58; 95% ci,1.06-2.36; p=.0148; adjusted or,1.64; 95% ci,1.10-2.45; p=.0217). furthermore,a novel finding of the present study was that this association was exclusive to males (adjusted or,1.79; 95% ci,1.06-3.05; p=.0308) and patients with higher immunoglobulin e levels (≥ 1.85 iu/ml) (adjusted or,1.88; 95% ci,1.10-3.22; p=.0213). we also found that the haplotype with minor alleles for rs763780 was associated with an increased risk of asthma (adjusted or,1.62; 95% ci,1.11-2.35; p=.0115). conclusion: our findings indicated that polymorphisms might play a role in susceptibility to asthma. © 2012 esmon publicidad.