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Genetic defects in B-cell development and their clinical consequences
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نویسنده
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abolhassani h. ,parvaneh n. ,rezaei n. ,hammarström l. ,aghamohammadi a.
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منبع
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journal of investigational allergology and clinical immunology - 2014 - دوره : 24 - شماره : 1 - صفحه:6 -22
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چکیده
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Expression of selected genes in hematopoietic stem cells has been identified as a regulator of differentiation of b cells in the liver and bone marrow. moreover,naïve b cells expressing surface immunoglobulin need other types of genes for antigen-dependent development in secondary lymphoid organs. many advanced molecular mechanisms underlying primary antibody deficiencies in humans have been described. we provide an overview of the mutations in genes known to be involved in b-cell development and their clinical consequences. © 2014 esmon publicidad.
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کلیدواژه
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B-cell development; Clinical phenotypes; Genetic disorder; Primary antibody deficiencies
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آدرس
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research center for immunodeficiencies,pediatrics center of excellence,children's medical center,tehran university of medical sciences,tehran,iran,division of clinical immunology,department of laboratory medicine,karolinska institutet at karolinska university hospital huddinge,stockholm, Sweden, research center for immunodeficiencies,pediatrics center of excellence,children's medical center,tehran university of medical sciences,tehran, ایران, research center for immunodeficiencies,pediatrics center of excellence,children's medical center,tehran university of medical sciences,tehran, ایران, division of clinical immunology,department of laboratory medicine,karolinska institutet at karolinska university hospital huddinge,stockholm, Sweden, research center for immunodeficiencies,pediatrics center of excellence,children's medical center,tehran university of medical sciences,tehran, ایران
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Authors
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