Effects of TNF-α polymorphisms on asthma risk: A systematic review and meta-analysis

Methods: a search was performed of the pubmed,embase,and wanfang databases. data were extracted and pooled ors with 95% cis were calculated.background: several studies have examined associations between tnf-α polymorphisms and asthma risk,but the results have been conflicting.results: fifty-four studies were included. a significant association between the tnfa -308a/g polymorphism and asthma susceptibility was observed for aa+ag vs gg (or,1.39; 95% ci,1.23-1.58; p<.001). this polymorphism was also significantly associated with asthma risk in whites (or,1.47; 95% ci,1.25-1.73; p<.001),atopic asthma risk (or,1.38; 95% ci,1.16-1.65; p<.001),pediatric asthma risk (or,1.48; 95% ci,1.23-1.79; p<.001),and adult asthma risk (or,1.35; 95% ci,1.21-1.52; p<.001). there was also a significant association between the tnfa -857c/t polymorphism and asthma risk in the recessive model (or,1.25; 95% ci,1.10-1.43; p<.001). in the subgroup analyses,asthma risk was significantly increased in asians (or,1.23; 95% ci,1.07-1.41; p=.004) and atopic individuals (or,1.33; 95% ci,1.13-1.57; p<.001). no significant association was found for the tnfa -238a/g polymorphism. there were insufficient data to evaluate the associations between tnfa -1031t/c and -863c/a polymorphisms and asthma risk.conclusions: this meta-analysis suggests that tnfa -308a/g and -857c/t polymorphisms are risk factors for asthma. © 2014 esmon publicidad.