Are basophil activation and sulphidoleukotriene determination useful tests for monitoring patients with peach allergy receiving sublingual immunotherapy with a Pru p 3-enriched peach extract?

Introduction: treatment of food allergy essentially consists of food avoidance,but immunotherapy with food is emerging as a new therapeutic option. objective: to evaluate clinical improvement and immunological changes in patients with peach allergy following sublingual immunotherapy (slit) with a pru p 3 quantified peach extract. methods: a randomized,double-blind,placebo-controlled clinical trial with peach slit was conducted. we assessed clinical efficacy after 6 months of treatment by means of double-blind,placebo-controlled oral challenges with peach and also evaluated immunological changes (basophil activation test [bat] and determination of sulphidoleukotriene production) following stimulation with peach peel and pulp,rpru p 3,rmal d 1,and rmal d 4 stimulation. we also measured specific ige and igg4 to pru p 3. results: after 6 months of slit (t6),the active group showed a 3-fold improvement in tolerance to pru p 3 and a significant increase in ige to rpru p 3 and in slt production following stimulation with peach peel and rpru p 3. there was also a significant increase in bat results after stimulation with rpru p 3 at 1 month of slit (t1). statistically significant between-group differences were only observed for bat with peach peel and pulp at t1 and t6 and for bat with rpru p 3 at t6. no changes were observed in bat with rmal d 1 or rmal d 4 or in igg4 levels to npru p 3. conclusions: slit with a pru p 3 quantified peach extract is clinically effective and leads to an increase in basophil activation and sulphidoleukotriene production following stimulation with rpru p 3 and peach peel in the first months of treatment. © 2014 esmon publicidad.