Interferon-γ +874A/T polymorphism is associated with asthma risk: A meta-analysis

Background: results regarding the association between the interferon-γ (ifn-γ) +874a/t polymorphism and asthma risk are controversial and ambiguous. the aim of this study was to determine with greater precision the relationship between the ifn-γ +874a/t polymorphism and asthma using a meta-analysis.methods: published literature was retrieved from 5 databases (pubmed,embase,wanfang,china national knowledge infrastructure [cnki] and weipu). ors with 95% cis were used to assess the strength of association.results: ten case-control studies involving 697 cases and 1049 controls were identified. in the overall analysis,a significant association between the +874a/t polymorphism and asthma susceptibility was found for aa vs at + tt (or,1.89; 95% ci,1.37-2.62; p=.0001). in the subgroup analysis by ethnicity,significant associations were found among whites (or,1.42; 95% ci,1.04-1.93; p=.03) and asians (or,2.52; 95% ci,1.49-4.25; p=.0006). the sensitivity analysis and cumulative meta-analysis further strengthened the validity of this association. no publication bias was observed in this study.conclusion: the results of this meta-analysis suggest that the ifn-γ +874a/t polymorphism is a risk factor for asthma. © 2014 esmon publicidad.