Association between cc motif chemokine ligand 5 (Ccl5) polymorphisms and asthma risk: An updated meta-analysis

Background: findings regarding the associations between the cc motif chemokine ligand 5 (ccl5)-403g/a and-28c/g polymorphisms and asthma risk are controversial. we performed a meta-analysis to determine whether ccl5 polymorphisms are associated with asthma risk. methods: we searched the pubmed,embase,chinese national knowledge infrastructure (cnki),and wanfang databases for studies published before june 2013. the strength of associations was calculated using ors with 95% cis. results: twenty case-control studies were included in this meta-analysis. we did not observe a significant association between the ccl5-403g/a polymorphism and asthma risk (or,1.10; 95% ci,0.93-1.30; p=.25). the ccl5-28c/g polymorphism,however,was associated with a significantly elevated asthma risk (or,1.17; 95% ci,1.02-1.33; p=.02). subgroup analyses found that the ccl5-28c/g polymorphism was significantly associated with asthma risk in asians (or,1.16; 95% ci,1.01-1.33; p=.04) and children (or,1.29; 95% ci,1.03-1.63; p=.03). conclusions: this meta-analysis suggests that the ccl5-28c/g polymorphism is a risk factor for asthma. © 2015 esmon publicidad.