Association between asthma and sensitization to allergens of Dermatophagoides pteronyssinus

Background: little is known about the role of molecular diagnosis in house dust mite (hdm) allergy. objective: in this study,we investigated the association between the sensitization profile of adolescent and adult hdm-allergic patients and asthma in a region with high rates of exposure to hdm. methods: we conducted a cross-sectional study of 384 hdm-allergic patients (38.5%,males; median age,28 years). a total of 368 patients (95.8%) had rhinitis,and 175 (45.6%) had asthma. specific ige (sige) to dermatophagoides pteronyssinus,nder p 1,rder p 2,and rpen a 1 was measured in all patients. sige to lepidoglyphus destructor was measured in patients (n=301) with a positive skin test result. results: significantly higher concentrations of sige to der p 1 and sige to der p 2 were observed in patients with asthma than in those without asthma. the proportion of asthmatic patients was higher among individuals who reacted (≥0.35 kua/l) to both der p 1 and der p 2 (147/291,50.5%) than among those who reacted to only 1 allergen (either der p 1 or der p 2,18/55,32.7%) or neither allergen (10/38,26.3%,p=.002). reactivity to both allergens was associated with asthma after adjusting for age and sex (or,2.87; 95%ci,1.32-6.20). higher concentrations of sige to l destructor were observed in patients with asthma than in patients without asthma. tropomyosin sige ≥0.35 kua/l was detected in only 6 individuals (1.6%). conclusions: l destructor may be a relevant allergen in high-exposure areas. dual sensitization (ie,ige to both der p 1 and der p 2) may help to identify hdm-allergic patients who are at risk of asthma. © 2016 esmon publicidad.