Is the quantification of antigen-specific basophil activation a useful tool for monitoring oral tolerance induction in children with egg allergy?

Objectives: to assess modifications in baseline specific ige-and anti-ige-and antigen-specific-mediated basophil activation in egg-allergic children. the values were compared before and after the children completed specific oral tolerance induction (soti) with egg. patients and methods: we studied 28 egg-allergic children who completed soti with egg. the basophil activation test and specific ige determinations with egg white,ovalbumin,and ovomucoid were performed in all 28 children. results: a decrease in antigen-specific activation with egg white,ovalbumin,and ovomucoid was observed only at the 2 lowest concentrations used (5 and 0.05 ng/ml). baseline activation was higher in patients with multiple food allergies and in those who developed anaphylaxis during soti; this activation decreased in both groups after completion of soti. a significant decrease was also observed in specific ige values for egg white,ovalbumin,and ovomucoid after tolerance induction. conclusions: food tolerance induction is a specific process for each food that can be mediated by immunologic changes such as a decrease in specific ige values and in specific and spontaneous basophil activation. © 2016 esmon publicidad.