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   Specific allergen immunotherapy for the treatment of allergic asthma: a review of current evidence  
   
نویسنده dominguez-ortega j. ,delgado j. ,blanco c. ,prieto l. ,arroabarren e. ,cimarra m. ,henriquez-santana a. ,iglesias-souto j. ,vega-chicote j.m. ,tabar a.i.
منبع journal of investigational allergology and clinical immunology - 2017 - دوره : 27 - شماره : Suppl. 1 - صفحه:1 -35
چکیده    Asthma is frequently associated with atopy,characterized by the production of specific immunoglobulin e in response to environmental allergens. currently,two types of allergen immunotherapy (ait) are used in clinical practice: subcutaneous and sublingual immunotherapy,both accepted as key components of the therapeutic repertoire for allergic rhinitis and conjunctivitis. however,their role in asthma remains controversial. the present document is aimed at providing the clinicians with a review of the evidence on the use of ait in asthma,focusing on the most relevant aspects of its mechanism of action,its efficacy,and existing data on safety,tolerability,and cost-effectivity,both in pediatric and adult populations. a systematic search of medline,cochrane,and clinical trials databases from 2000 to april of 2016 was carried out by a panel of experts from the spanish allergy and clinical immunology scientific society. relevant studies prior to the year 2000 included in ulterior systematic reviews were also considered. more than 4000 articles were identified during the search and 241 were selected to retrieve available evidence on ait,which was graded according to the oxford classification. all the group members reviewed the resulting text until the final version reached the consensual agreement. a summary of recommendations on the more relevant topics are proposed. the role of ait as a valuable therapeutic strategy for prevention of exacerbation and progressive decline in lung function is highlighted. future research should include specific tools for asthma evaluation when assessing ait effectiveness in asthmatic patients.
کلیدواژه Adults; Allergen immunotherapy; Asthma treatment; Children; Cost-effectiveness.; Efficacy; Safety; SCIT; Severe asthma; SLIT
آدرس servicio de alergología,instituto de investigación sanitaria del hospital universitario la paz (idipaz),ciber de enfermedades respiratorias,ciberes,madrid, Spain, unidad de gestión clínica de alergología,hospital virgen macarena,sevilla, Spain, servicio de alergia,hospital universitario de la princesa,instituto de investigación sanitaria princesa (ip),madrid, Spain, sección de alergología and universidad de valencia,valencia, Spain, servicio de alergología,complejo hospitalario de navarra,pamplona, Spain, servicio de alergología,hospital clínico universitario san carlos,madrid, Spain, servicio de alergología,hospital universitario infanta elena (valdemoro),madrid, Spain, servicio de alergología,hospiten sur,tenerife, Spain, unidad de gestión clínica de alergología,hospital regional universitario de málaga, Spain, servicio de alergología,complejo hospitalario de navarra,pamplona,spain,instituto de investigación sanitaria de navarra (idisna),retic de asma,reacciones adversas y alérgicas (aradyal),pamplona, Spain
 
     
   
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