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Role of glycogen synthase kinase-3 beta in the inflammatory response caused by bacterial pathogens
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نویسنده
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cortés-vieyra r. ,bravo-patiño a. ,valdez-alarcón j.j. ,juárez m.c. ,finlay b.b. ,baizabal-aguirre v.m.
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منبع
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journal of inflammation - 2012 - دوره : 9 - شماره : 0
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چکیده
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Glycogen synthase kinase 3β (gsk3β) plays a fundamental role during the inflammatory response induced by bacteria. depending on the pathogen and its virulence factors,the type of cell and probably the context in which the interaction between host cells and bacteria takes place,gsk3β may promote or inhibit inflammation. the goal of this review is to discuss recent findings on the role of the inhibition or activation of gsk3β and its modulation of the inflammatory signaling in monocytes/macrophages and epithelial cells at the transcriptional level,mainly through the regulation of nuclear factor-kappab (nf-κb) activity. also included is a brief overview on the importance of gsk3 in non-inflammatory processes during bacterial infection. © 2012 cortés-vieyra et al.; licensee biomed central ltd.
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کلیدواژه
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Bacterial infection; GSK3β; Inflammation; NF-κB; Virulence factors
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آدرس
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centro multidisciplinario de estudios en biotecnología,facultad de medicina veterinaria y zootecnia,universidad michoacana de san nicolás de hidalgo,morelia,michoacán, Mexico, centro multidisciplinario de estudios en biotecnología,facultad de medicina veterinaria y zootecnia,universidad michoacana de san nicolás de hidalgo,morelia,michoacán, Mexico, centro multidisciplinario de estudios en biotecnología,facultad de medicina veterinaria y zootecnia,universidad michoacana de san nicolás de hidalgo,morelia,michoacán, Mexico, centro multidisciplinario de estudios en biotecnología,facultad de medicina veterinaria y zootecnia,universidad michoacana de san nicolás de hidalgo,morelia,michoacán, Mexico, michael smith laboratories,university of british columbia,vancouver,bc v6t 1z4, Canada, centro multidisciplinario de estudios en biotecnología,facultad de medicina veterinaria y zootecnia,universidad michoacana de san nicolás de hidalgo,morelia,michoacán,mexico,centro multidisciplinario de estudios en biotecnología,facultad de medicina veterinaria y zootecnia,universidad michoacana de san nicolás de hidalgo,km. 9.5 s/n carretera morelia-zinapécuaro,la palma,tarimbaro,c.p. 58893,morelia,michoacán, Mexico
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Authors
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